Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450
نویسندگان
چکیده
منابع مشابه
Isolation and Structure Elucidation of Secondary Metabolites from Echinophora platyloba DC from Iran
Background: Echinophora platyloba DC (Apiaceae) is one of the two endemic species of Echinophora genus in Iran. It has many folkloric uses and several biological activities but there is no information about its phytoconstituents. Objective: In this work some of the secondary metabolites were isolated, purified and identified from n-hexane, ethyl acetate and methanol extracts from the aerial pa...
متن کاملMetabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate.
Medroxyprogesterone acetate (MPA) is one of the most frequently prescribed progestins for conception, hormone replacement therapy, and adjuvant endocrine therapy. MPA has a low oral bioavailability because of extensive metabolism; however, its metabolism was poorly documented. This study was intended to profile the phase I metabolites of MPA and the cytochrome P450 (P450) isoforms involved. Aft...
متن کاملSubcutaneous depo-medroxyprogesterone acetate.
To cite: Cameron S. Journal of Family Planning and Reproductive Health Care 2013;39:75–77. INTRODUCTION Since 2004, a micronised formulation of depo-medroxyprogesterone acetate (DMPA) that is delivered as a subcutaneous injection has been available. It is currently in clinical use in the USA and in nine countries throughout Europe. As of March 2013 this product is being marketed in the UK as Sa...
متن کاملisolation and structure elucidation of secondary metabolites from echinophora platyloba dc from iran
background: echinophora platyloba dc (apiaceae) is one of the two endemic species of echinophora genus in iran. it has many folkloric uses and several biological activities but there is no information about its phytoconstituents. objective: in this work some of the secondary metabolites were isolated, purified and identified from n-hexane, ethyl acetate and methanol extracts from the aerial par...
متن کاملRole of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.
Medroxyprogesterone acetate (MPA) is a drug commonly used in endocrine therapy for advanced or recurrent breast cancer and endometrial cancer. The drug is extensively metabolized in the intestinal mucosa and in the liver. Cytochrome P450s (CYPs) involved in the metabolism of MPA were identified by using human liver microsomes and recombinant human CYPs. In this study, the overall metabolism of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2009
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.57.835